Type 1 Responses of Human Vγ9Vδ2 T Cells to Influenza A Viruses
Identifieur interne : 002A11 ( Main/Exploration ); précédent : 002A10; suivant : 002A12Type 1 Responses of Human Vγ9Vδ2 T Cells to Influenza A Viruses
Auteurs : GANG QIN [Hong Kong, République populaire de Chine] ; YINPINGLIU [Hong Kong] ; JIAN ZHENG [Hong Kong] ; Iris H. Y. Ng [Hong Kong] ; ZHENG XIANG [Hong Kong] ; Kwok-Tai Lam [Hong Kong] ; HUAWEI MAO [Hong Kong] ; HONG LI [Hong Kong] ; J. S. Malik Peiris [Hong Kong] ; Yu-Lung Lau [Hong Kong] ; WENWEI TU [Hong Kong]Source :
- Journal of virology [ 0022-538X ] ; 2011.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
γδ T cells are essential constituents of antimicrobial and antitumor defenses. We have recently reported that phosphoantigen isopentenyl pyrophosphate (IPP)-expanded human Vγ9Vδ2 T cells participated in anti-influenza virus immunity by efficiently killing both human and avian influenza virus-infected monocyte-derived macrophages (MDMs) in vitro. However, little is known about the noncytolytic responses and trafficking program of γδ T cells to influenza virus. In this study, we found that Vγ9Vδ2 T cells expressed both type 1 cytokines and chemokine receptors during influenza virus infection, and IPP-expanded cells had a higher capacity to produce gamma interferon (IFN-γ). Besides their potent cytolytic activity against pandemic H1N1 virus-infected cells, IPP-activated γδ T cells also had noncytolytic inhibitory effects on seasonal and pandemic H1N1 viruses via IFN-γ but had no such effects on avian H5N1 or H9N2 virus. Avian H5N1 and H9N2 viruses induced significantly higher CCL3, CCL4, and CCL5 production in Vγ9Vδ2 T cells than human seasonal H1N1 virus. CCR5 mediated the migration of Vγ9Vδ2 T cells toward influenza virus-infected cells. Our findings suggest a novel therapeutic strategy of using phosphoantigens to boost the antiviral activities of human Vγ9Vδ2 T cells against influenza virus infection.
Affiliations:
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Le document en format XML
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<country>Hong Kong</country>
<wicri:noRegion>Joint Research Centre, West China Second University Hospital, Sichuan University and the Department of Paediatrics and Adolescent Medicine, University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Human</term>
<term>Influenza A virus</term>
<term>T-Lymphocyte</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Homme</term>
<term>Virus grippal A</term>
<term>Lymphocyte T</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">γδ T cells are essential constituents of antimicrobial and antitumor defenses. We have recently reported that phosphoantigen isopentenyl pyrophosphate (IPP)-expanded human Vγ9Vδ2 T cells participated in anti-influenza virus immunity by efficiently killing both human and avian influenza virus-infected monocyte-derived macrophages (MDMs) in vitro. However, little is known about the noncytolytic responses and trafficking program of γδ T cells to influenza virus. In this study, we found that Vγ9Vδ2 T cells expressed both type 1 cytokines and chemokine receptors during influenza virus infection, and IPP-expanded cells had a higher capacity to produce gamma interferon (IFN-γ). Besides their potent cytolytic activity against pandemic H1N1 virus-infected cells, IPP-activated γδ T cells also had noncytolytic inhibitory effects on seasonal and pandemic H1N1 viruses via IFN-γ but had no such effects on avian H5N1 or H9N2 virus. Avian H5N1 and H9N2 viruses induced significantly higher CCL3, CCL4, and CCL5 production in Vγ9Vδ2 T cells than human seasonal H1N1 virus. CCR5 mediated the migration of Vγ9Vδ2 T cells toward influenza virus-infected cells. Our findings suggest a novel therapeutic strategy of using phosphoantigens to boost the antiviral activities of human Vγ9Vδ2 T cells against influenza virus infection.</div>
</front>
</TEI>
<affiliations><list><country><li>Hong Kong</li>
<li>République populaire de Chine</li>
</country>
</list>
<tree><country name="Hong Kong"><noRegion><name sortKey="Gang Qin" sort="Gang Qin" uniqKey="Gang Qin" last="Gang Qin">GANG QIN</name>
</noRegion>
<name sortKey="Hong Li" sort="Hong Li" uniqKey="Hong Li" last="Hong Li">HONG LI</name>
<name sortKey="Huawei Mao" sort="Huawei Mao" uniqKey="Huawei Mao" last="Huawei Mao">HUAWEI MAO</name>
<name sortKey="Jian Zheng" sort="Jian Zheng" uniqKey="Jian Zheng" last="Jian Zheng">JIAN ZHENG</name>
<name sortKey="Lam, Kwok Tai" sort="Lam, Kwok Tai" uniqKey="Lam K" first="Kwok-Tai" last="Lam">Kwok-Tai Lam</name>
<name sortKey="Lau, Yu Lung" sort="Lau, Yu Lung" uniqKey="Lau Y" first="Yu-Lung" last="Lau">Yu-Lung Lau</name>
<name sortKey="Malik Peiris, J S" sort="Malik Peiris, J S" uniqKey="Malik Peiris J" first="J. S." last="Malik Peiris">J. S. Malik Peiris</name>
<name sortKey="Ng, Iris H Y" sort="Ng, Iris H Y" uniqKey="Ng I" first="Iris H. Y." last="Ng">Iris H. Y. Ng</name>
<name sortKey="Ng, Iris H Y" sort="Ng, Iris H Y" uniqKey="Ng I" first="Iris H. Y." last="Ng">Iris H. Y. Ng</name>
<name sortKey="Wenwei Tu" sort="Wenwei Tu" uniqKey="Wenwei Tu" last="Wenwei Tu">WENWEI TU</name>
<name sortKey="Wenwei Tu" sort="Wenwei Tu" uniqKey="Wenwei Tu" last="Wenwei Tu">WENWEI TU</name>
<name sortKey="Yinpingliu" sort="Yinpingliu" uniqKey="Yinpingliu" last="Yinpingliu">YINPINGLIU</name>
<name sortKey="Zheng Xiang" sort="Zheng Xiang" uniqKey="Zheng Xiang" last="Zheng Xiang">ZHENG XIANG</name>
</country>
<country name="République populaire de Chine"><noRegion><name sortKey="Gang Qin" sort="Gang Qin" uniqKey="Gang Qin" last="Gang Qin">GANG QIN</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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